Trimethylsilyl Trifluorometh Anesulfonate CAS No. 27607-77-8 High Quality 99% Supplier in China

• CAS No.: 27607-77-8
• Formula: C4h9f3o3ssi
• EINECS: 248-565-4
• Type: Pharmaceutical Intermediates
• Appearance: Liquid
• Quality: Good Chemical Product
• Model NO.: JT22PHA
• Colour: Colorless
• Name: Trimethylsilyl Trifluorometh Anesulfonate
• Formula Weight: 222.26
• Color: Colorless Transparent
• Assay: 99%
• Delivery: by Sea, by Air, by Land/EMS/TNT/DHL/UPS/FedEx
• Application: an Important Raw Material
• Storage Temp: Room Temperature and Avoid Light
• Standard: Good Chemical Product
• Transport Package: 25kg/Bag, Customization
• Specification: 25kg,50kg,180kg,200kg,250kg,1000kg,customization
• Trademark: Hubei Jiutian
• Origin: Wuhan
• HS Code: 29310095
• Production Capacity: 15mt/Month

Product Description

Trimethylsilyl trifluorometh anesulfonate Basic information

CT3795;Meth anesulfonic acid, trifluoro-, trimethylsilyl ester;SI LANE TMS-TRIFLATE;TMSOTF;TMS TRIFLATE;TRIMETHYLSILYL TRIFLATE;TRIMETHYLSILYL TRIFLUOROMETH ANESULFONATE;TRIMETHYLSILYL TRIFLUOROMETH ANESULPHONATE
Trimethylsilyl Trifluorometh anesulfonate is generally used following reactions:1. Silylation. TMSOTf is widely used in the conversion of carbonyl compounds to their enol ethers. The conversion is some 109 faster with TMSOTf/triethyla mine than with chlorotrimethylsi lane.

Dicarbonyl compounds are converted to the corresponding bisenol ethers; this method is an improvement over the previous twostep method.In general, TMSOTf has a tendency toC-silylation which is seen most clearly in the reaction of esters, whereC-silylation dominates over O-silylation.

2.Carbonyl Activation. 1,3-Dioxolanation of conjugated enals is facilitated by TMSOTf in the presence of 1,2-bis(trimethylsilyloxy)eth ane. In particular, highly selective protection of sterically differentiated ketones is possible (eq 10).TMSOTf mediates a stereoselective aldol-type condensation of silyl enol ethers and ace tals (or orthoesters). The nonbasic reaction conditions are extremely mild. The use of TMSOTf in aldol reactions of silyl enol ethers and ketene ace tals with aldehydes is ubiquitous.Stereoselective cyclization of α,β-unsaturated enamide esters is induced by TMSOTf and has been used as a route to quinolizidines and indolizidines
4.The often difficult conjugate addition of alkynyl organometallic reagents to enones is greatly facilitated by TMSOTf. In particular, alkynyl zinc reagents (normally unreactive with α,β-unsaturated carbonyl compounds) add in good yield.The formation of nitrones by reaction of aldehydes and ketones with N-methyl-N,O-bis(trimethylsilyl)hydroxylamine is accelerated when TMSOTf is used as a catalyst; the acceleration is particularly pronounced when the carbonyl group is under a strong electronic influence.5. Methyl glucopyranosides and glycopyranosyl chlorides undergo allylation with allylsi lanes under TMSOTf catalysis to give predominantly α-allylated carbohydrate analogs.Glycosidation is a reaction of massive importance and widespread employment. TMSOTf activates many selective glycosidation reactions.
5.O-Silylation. The formation of TMS ethers can be achieved by reacting the requisite alcohol with TMSOTf and an amine (triethyla mine, pyri dine, or 2,6 -lutidine) in dichlorometh ane;C-Silylation. Depending on the reaction conditions, secondary amides can be either C-silylated or N-silylated;N-Silylation. The N-bis-silylation of α-amino acids with TMSOTf is only effective for glycine; for other α-amino acids N-mono-silylation prevails because the larger size of the carbon chain at the α-position hinders bis-silylation;C,O-Bis-silylation. Bis-silylation ofα,β-unsaturated carbonyl compounds can be achieved by palladium-TMSOTf-catalyzed addition of disi lanes to enones, enals, or aromatic aldehydes via an η3-silyloxyallylpalladium intermediate;Carbonyl Activation. TMSOTf frequently acts as a Lewis acid and it is able to activate several functional groups (the carbonyl group, the ace tal unit, the nitrone moiety,…) thus facilitating different kinds of reactions;Ace tal Activation. TMSOTf acts as a catalyst for the addition of several nucleophiles (allylsi lanes, allylstannanes, silyl enol ethers, trimethylsilyl cyanide) towardN,O-ace tals;Nitrone Activation. The nucleophilic addition to aldonitrones depends on the nature of the metal involved and the presence/absence of an activator;Epoxide Ring Opening. One-pot alkylation-O-silylation reactions of epoxides take place in excellent yields;Cleavage of Protecting Groups. THP ethers of primary, secondary, and phenolic alcohols can be conveniently deprotected at room temperature; Hypervalent Iodine Chemistry. The formation of hypervalent iodine complexes is often promoted by TMSOTf.
Trimethylsilyl Trifluorometh anesulfonate is a trialkylsilyl triflate used as a catalyst in organic synthesis. Trimethylsilyl Trifluorometh anesulfonate is used in combination with boron  trifluoride eth yl ether to prepare a Lewis acid that is more powerful than its components and especially effective in ace tonitrile solvent. Trimethylsilyl is a common reagent used in a Dieckmann-like cyclization of ester-imides and diesters.
product details

Item	parameter
Name	Trimethylsilyl trifluorometh anesulfonate
Synonyms	CT3795
CAS	27607-77-8
Molecular Formula	C4H9F3O3SSi
Formula Weight	222.26
Appearance	Colorless transparent liquide
Melting Point	25°C
Boiling point	77 °C/80 mmHg (lit.)
Assay	99%
Water	<0.5%
Residue on ignition	<0.5%
Stability	Stable
Storage Temp	room temperature and avoid light
Origin	Wuhan China
Application	an important raw material
Delivery	by sea,by air,by Land/EMS/TNT/DHL/UPS/FedEx

Packing                                                                                                                                     

Liquid products

• 25kg,50kg,180kg,200kg,250kg,1000kg,as your needs

Solid products

• 25kg,50kg,as your needs

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Logistics transportation methods can be divided into various ways according to the different transportation means.

• Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
• For mass orders, it will be delivered by air or sea.
• Depending on your location, please allow 1-5 business days for your order to arrive.
• For small order, please expect 3-7 days by UPS DHL EMS.
• For mass order, please allow 5-8 days by Air, 15-30 days by Sea.

 

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• We have our own research and development team, laboratory, pilot workshop and production plant.
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Frequently Asked Question                                                                                                      

• Q1: Can I get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by customers.

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• Q3: What's your MOQ?
A : Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that 
sample charge is 100% paid.
• Q4: How about delivery leadtime?
A : Delivery lead time: About 3-5 days after payment confirmed.(Chinese holiday not

included)

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A : Different quantity has different discount.

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