N-Acetylsulfanilyl chloride Basic information
ASC;4-ACETYLAMINO BENZENESULFONYL CHLORIDE;4-ACETAMIDOPHENYLSULFONYL CHLORIDE;4-ACETAMIDOBENZENESULFONYL CHLORIDE;4-ACETAMIDOBENZENESULPHONYL CHLORIDE;-(acetylamino)benzenesulfonylchloride;4-(acetylamino)-benzenesulfonylchlorid;4'-(Chlorosulfonyl)ace tanilide
A sulfanilamide derivative of Chitosan
Intermediate in the preparation of sulfanilamide and its derivatives.
N-Acetylsulfanilyl chloride is used?in the preparation of sulfanilamide and its derivatives which are intermediates to produce sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. It is also used as a Pharma raw material. N-Acetylsulfanilyl chloride widely used in the fields of dye, medicine, mainly used for preparation of Sulfanilamide, Sulfanilylureal, Sulfatolamide, Sulphathiourea , Sulfaguanidine and Sulfacetamide and etc.
After more than three decades of strain and process optimization, the 2KGA fermentation by K. vulgare has reached a performance level that makes it increasingly difficult to achieve further cost-relevant improvements. Instead, opportunities can be seen in the succeeding step of 2KGA rearrangement to ascorbic acid, which still follows the same concept as laid out in the 1930s by Reichstein and Grüssner. This chemical step contributes significantly to the overall process costs. A process Industrial Production of L-Ascorbic Acid (Vitamin C) and D-Isoascorbic Acid 171 concept that could convert sorbitol directly to ascorbic acid would therefore be most attractive. In theory, this could build on the established 2KGA fermentation with an enzyme-catalyzed 2KGA to Asc rearrangement (2,6-hemiacetal to 1,4- lactone) as extension. Ab initio energy calculations as well as experimental results (own unpublished results) indicate that in aqueous environment, Asc is thermodynamically far more stable than 2KGA and (nearly) quantitative conversion should be possible. However, no enzyme efficiently catalyzing this reaction has so far been identified. The few publications of enzyme catalysis for this reaction so far shows only trace activity and no significant improvements have been reported. 2KGA may represent a kinetic trap in an aqueous environment and biotechnological reaction pathways all the way to Asc may need to avoid 2KGA. Accordingly, 2KGA is also not part of natural biosynthetic routes, where Asc formation directly results from the oxidation of precursor molecules with appropriately preformed 1,4-lactone linkage (L-gulono-1,4-lactone in animals, L-galactono-1,4-lactone in plants). Enzymes converting L-gulono-1,4-lactone to Asc are also known from bacteria, even from Ketogulonicigenium. The biochemical description of the Ketogulonicigenium enzyme indicates that it belongs to the family of heterotrimeric periplasmic flavohemoproteins, of which several can be found in the published Ketogulonicigenium genomes. Besides sharing the same FAD cofactor, these enzymes bear no similarity to the mammalian gulono-1,4- lactone dehydrogenase. The use of these natural or nature-like Asc-forming enzymatic steps in biotechnological production processes is so far precluded by the rare nature of these L-sugar-derived lactone precursor molecules and the lack of efficient production methods for these compounds. It was, therefore, a tantalizing discovery when Asc formation directly from L-sorbosone, the intermediate of the efficient 2KGA formation route, was identified in those two species already in the focus for 2KGA production for decades: K. vulgare and G. oxydans. Besides an earlier report of L-sorbosone to Asc activity derived from plant tissue , which did not see consolidating follow-ups, the above observations are the first evidence of biological Asc formation from a molecule other than a 1,4-lactone.
| Item |
parameter |
| Name |
N-Acetylsulfanilyl chloride |
| Synonyms |
ASC |
| CAS |
121-60-8 |
| Molecular Formula |
C8H8ClNO3S |
| Formula Weight |
233.67 |
| Appearance |
white powder |
| Melting Point |
142-145 °C (dec.)(lit.) |
| Boiling point |
426.8±28.0 °C(Predicted) |
| Assay |
99% |
| Water |
<0.5% |
| Residue on ignition |
<0.5% |
| Stability |
Stable |
| Storage Temp |
room temperature and avoid light |
| Origin |
Wuhan China |
| Application |
Sulfonamide |
| Delivery |
by land/EMS/TNT/DHL/UPS/FEDEX |
Packing
Liquid products
- 25kg,50kg,180kg,200kg,250kg,1000kg,as your needs
Solid products
Shipping
Logistics transportation methods can be divided into various ways according to the different transportation means.
• Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
• For mass orders, it will be delivered by air or sea.
• Depending on your location, please allow 1-5 business days for your order to arrive.
• For small order, please expect 3-7 days by UPS DHL EMS.
• For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
Our service
- We have our own research and development team, laboratory, pilot workshop and production plant.
- Factory production has the most stable and the best production processes, to ensure that you are given the best prices and the highest quality products.
- Not only do we provide our customers with products, but we also provide them with free product usage methods and subsequent technical guidance
- The customer comes first, we provide reasonable price, high quality product and prompt shipment.
- We can send the goods to your delivery address directly. It is relatively safe and fast. We have ready goods in stock.
- Quick and clear response to customers questions.Warm after sale service, we will help to solve the problems in your usage.
- We could make our price discount if you place a substantial order with us.
Our Advantages
- Your inquiry related to our products or prices will be replied in 24 hours.
- We have our own research and development team, laboratory, pilot workshop and production plant.
- Factory production has the most stable and the best production processes, to ensure that you are given the best prices and the highest quality products.
- Not only do we provide our customers with products, but we also provide them with free product usage methods and subsequent technical guidance
- Protection of your sales area, ideas of design and all your private information.
- Best quality and competitive price.
Frequently Asked Question
• Q1: Can I get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by customers.
• Q2: How to start orders or make payments?
A : PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union LC,Moneygram or Paypal.
• Q3: What's your MOQ?
A : Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that
sample charge is 100% paid.
• Q4: How about delivery leadtime?
A : Delivery lead time: About 3-5 days after payment confirmed.(Chinese holiday not
included)
• Q5: Is there a discount?
A : Different quantity has different discount.
• Q6: How to contact us ?
A : You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.
• Q7: How to confirm the Product Quality before placing orders?
A : You can get free samples for some products,you only need to pay the shipping cost or
arrange a courier to us and take the samples. You can send us your product specifications
and requests,we will manufacture the products according to your requests.
Our R&D laboratory Our Factory
Detecting chamber
Quality
We strictly emphasize that products we provide will satisfy or exceed the quality standard of customer.This is to guarantee deliveries of safe and high quality products with reliable services.
We promote the philosophy of treating everyone with objectivity and respect.We will honor our commitments with our customers,suppliers,and respect.We through unbiased pricing,products,and honesty.
Factories and workshops
We is located in wuhan, the central city of China, the core of the Changjiang river economic belt and known as the "thoroughfare of nine provinces".Mainly engaged in Pharmaceuticals Raw Material, Pesticides Raw Materials, API Raw Material, OLED Intermediates, UV Absorber Additive, Chemical Food Additives, Plant Extract Powder, Chinese Herbal Medicine, Polyimide Monomer, Impurity Reference Standards research and development, production, sales and operation or agency of various products and technology import and export business.
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